NITROGEN AND SULFUR CONTAINING HETEROCYCLES. 50. SYNTHESIS AND REACTIONS OF 6-OXOPYRIMIDO[4,5-<i>b</i>][1,4]THIAZINE-7-CARBOXYLIC ACID DERIVATIVES

Authors

  • T. C. Сафонова Center for Chemistry of Drugs - All-Russian Research Chemical-Pharmaceutical Institute
  • А. Ф. Керемов Center for Chemistry of Drugs - All-Russian Research Chemical-Pharmaceutical Institute

DOI:

https://doi.org/10.1007/670

Abstract

Reaction of 5-amino-6 mercaptopyrimidines with diethyl bromomalonate gave ethyl 6-oxopyrimido-[4,5-b][1,4]thiazine-7-carboxylates, from which there was synthesized a series of derivatives at the carboxyl group (amides, hydrazides, and, from the latter, urethanes). Desulfurization of the 6-oxo-pyrimidothiazine-7-carboxylic acid esters gave N-(pyrimidin-5-yl)monoamides of ethyl malonate.

Authors: T. S. Safonova and A. F. Keremov.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (6), pp 733-739

http://link.springer.com/article/10.1007/BF02251635

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Published

2013-06-03

Issue

No. 6 (1999)

Section

Original Papers