NITROGEN OXIDE GENERATION DURING REDUCTION OF NITROFURAN ANTIBACTERIAL DRUGS

Abstract

Proof of the nitrogen oxide generation during the chemical reduction of a series of nitrofuran derivatives is obtained by polarographic detection of the nitroprusside anion. A hypothesis is made about the mechanism of the peroxynitrite anion formation, which is responsible for the biological activity of nitrofurans during the course of their reduction.

Authors: N. B. Grigor'ev, G. V. Chechekin, A. P. Arzamaztsev, V. I. Levina, and V. G. Granik.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (7), pp 788-791

http://link.springer.com/article/10.1007/BF02252100