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SYNTHESIS, STRUCTURE, AND BIOLOGICAL ACTIVITY OF 4-HETARYL-2-PYRROLIDONES CONTAINING A PYRAZOLE RING

Наталья В. Городничева, Ольга С. Васильева, Евгений С. Остроглядов, Руслан И. Байчурин, Игорь А. Литвинов, Иван Н. Тюренков, Николай С. Ковалев, Дмитрий А. Бакулин, Денис В. Куркин, Лариса В. Байчурина, Сергей В. Макаренко
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Abstract


Single diastereomers of 4-hetaryl-2-pyrrolidone-3(5)-carbo- and 2-[4-hetaryl-2-pyrrolidon-1-yl]acetohydrazides were used in reactions with 2,4-pentanedione, providing (3R*,4S*)-3-, (4R*,5R*)-5-(3,5-dimethyl-1H-pyrazole-1-carbonyl)- and 1-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-2-oxoethyl]-4-hetaryl-2-pyrrolidones. The structures of the synthesized compounds were confirmed by spectral methods and X-ray structural analysis. Some of the obtained compounds were shown to possess nootropic and anxiolytic activity.

Authors: Natal'ya V. Gorodnicheva, Olga S. Vasil'eva, Evgeny S. Ostroglyadov,
Ruslan I. Baichurin, Igor A. Litvinov, Ivan N. Tyurenkov, Nikolay S. Kovalev,
Dmitry A. Bakulin, Denis V. Kurkin, L. V. Baichurina, Sergey V. Makarenko*


Keywords


carbohydrazides; 3,5-dimethylpyrazole; hydrazides; 2-pyrrolidone; biological activity; racetams; X-ray structural analysis

Full Text: PDF (Russian) Supplementary File(s): Supporting information (2MB)


 

 

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