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SYNTHESIS OF NOVEL γ-BUTYROLACTONE-BASED PHENAZINE COMPOUNDS VIA MICROWAVE-ASSISTED MULTICOMPONENT DOMINO REACTIONS

Ha-Thanh Nguyen, Phuong Hoang Thi, Giang Le-Nhat-Thuy, Quynh Giang Nguyen Thi, Tuan Anh Nguyen, Tuyet Anh Dang Thi, Tuyen Van Nguyen
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Abstract


A series of new and significative γ-butyrolactone-based phenazines were synthesized through two-step one-pot five-component reactions of 2-hydroxy-1,4-naphthoquinone, a variety of aromatic aldehydes, benzene-1,2-diamine, tetronic acid, and ammonium acetate in glacial acetic acid. The synthesis proceeded via condensation, Michael addition, tautomerization sequence of steps. All the synthesized compounds were fully characterized by spectral data.


Keywords


γ-butyrolactone; naphthoquinone; phenazine; microwave-assisted multicomponent reaction

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