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A NOVEL AND SIMPLE SYNTHESIS OF ETHERS OF HYDROXYPYRIDINES WITH HEXAFLUOROPROPAN-2-OL VIA DIAZOTIZATION OF AMINOPYRIDINES AND AMINOQUINOLINES UNDER ACID-FREE CONDITIONS

Victor D. Filimonov, Aldar N. Sanzhiev, Roman O. Gulyaev, Elena A. Krasnokutskaya, Alexander A. Bondarev
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Abstract


Herein, we report the first example of diazotization of aminopyridines and aminoquinolines with t-BuONO in hexafluoropropan-2-ol in the absence of acids or other initiators. For aminopyridines, this reaction is the first general route toward 2-, 3-, and 4-[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]pyridines.

Keywords


aminopyridines; aminoquinolines; anilines; ethers; 1,1,1,3,3,3-hexafluoropropan-2-ol; diazotization.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv