A NOVEL AND SIMPLE SYNTHESIS OF ETHERS OF HYDROXYPYRIDINES WITH HEXAFLUOROPROPAN-2-OL <i>VIA</i> DIAZOTIZATION OF AMINOPYRIDINES AND AMINOQUINOLINES UNDER ACID-FREE CONDITIONS

Authors

  • Victor D. Filimonov The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave., Tomsk 634050, Russia
  • Aldar N. Sanzhiev The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave., Tomsk 634050, Russia
  • Roman O. Gulyaev The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave., Tomsk 634050, Russia
  • Elena A. Krasnokutskaya The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave., Tomsk 634050, Russia
  • Alexander A. Bondarev Department of Biomedicine, Altai State University, 61 Lenina Ave., Barnaul 656049, Russia

DOI:

https://doi.org/10.1007/6851

Keywords:

aminopyridines, aminoquinolines, anilines, ethers, 1, 3, 3-hexafluoropropan-2-ol, diazotization.

Abstract

Herein, we report the first example of diazotization of aminopyridines and aminoquinolines with t-BuONO in hexafluoropropan-2-ol in the absence of acids or other initiators. For aminopyridines, this reaction is the first general route toward 2-, 3-, and 4-[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]pyridines.

Author Biographies

Victor D. Filimonov, The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave., Tomsk 634050, Russia

The Kizhner Research Center, professor

Aldar N. Sanzhiev, The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave., Tomsk 634050, Russia

The Kizhner Research Center, assistant

Roman O. Gulyaev, The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave., Tomsk 634050, Russia

The Kizhner Research Center, PhD student

Elena A. Krasnokutskaya, The Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenina Ave., Tomsk 634050, Russia

The Kizhner Research Center, director

Alexander A. Bondarev, Department of Biomedicine, Altai State University, 61 Lenina Ave., Barnaul 656049, Russia

Department of Biomedicine, researcher

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Published

2022-12-20

Issue

Vol. 58 No. 12 (2022)

Section

Original Papers