A REGIOSELECTIVE SYNTHESIS OF IMIDAZOTHIAZOLOTRIAZINES BASED ON THE CYCLIZATION OF IMIDAZOTRIAZINETHIONES WITH PHENACYL BROMIDES

Authors

  • Дмитрий Б. Виноградов N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Алексей Н. Изместьев N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Ангелина Н. Кравченко N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Галина А. Газиева N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

DOI:

https://doi.org/10.1007/6856

Keywords:

phenacyl bromides, thiazoles, 1, 2, 4-triazines, Hantzsch reaction, regioselectivity.

Abstract

Novel imidazothiazolotriazines were obtained as a result of the reaction of imidazo[4,5-e][1,2,4]triazine-3-thiones with various phenacyl  bromides. It was shown that the cyclocondensation proceeds with high regioselectivity leading to the formation of linear 7-arylimidazo-[4,5-e]thiazolo[3,2-b][1,2,4]triazines.

 

Author Biographies

Дмитрий Б. Виноградов, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

аспирант лаборатории азотсодержащих соединений

Алексей Н. Изместьев, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

н.с. лаборатории азотсодержащих соединений

Ангелина Н. Кравченко, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

в.н.с. лаборатории азотсодержащих соединений

Галина А. Газиева, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

Russian Academy of sciences

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Published

2022-10-21

Issue

Vol. 58 No. 10 (2022): Chemistry of polyheteroatomic heterocyclic systems

Section

Original Papers