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A REGIOSELECTIVE SYNTHESIS OF IMIDAZOTHIAZOLOTRIAZINES BASED ON THE CYCLIZATION OF IMIDAZOTRIAZINETHIONES WITH PHENACYL BROMIDES

Дмитрий Б. Виноградов, Алексей Н. Изместьев, Ангелина Н. Кравченко, Галина А. Газиева
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Abstract


Novel imidazothiazolotriazines were obtained as a result of the reaction of imidazo[4,5-e][1,2,4]triazine-3-thiones with various phenacyl  bromides. It was shown that the cyclocondensation proceeds with high regioselectivity leading to the formation of linear 7-arylimidazo-[4,5-e]thiazolo[3,2-b][1,2,4]triazines.

 


Keywords


phenacyl bromides; thiazoles; 1,2,4-triazines; Hantzsch reaction; regioselectivity.

Full Text: PDF (Russian) Supplementary File(s): Supplementary information (3MB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv