SYNTHESIS OF <i>S</i>-SUBSTITUTED 5-SULFONYLMETHYL(ETHYL)-1,3,4-THIADIAZOL-2-AMINES

Authors

  • Сергей А. Серков N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Наталья В. Сигай N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Наталия Н. Костикова N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Александр Е. Федоров N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia
  • Антон П. Тюрин Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., Moscow 117997, Russia
  • Галина А. Газиева N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

DOI:

https://doi.org/10.1007/6883

Keywords:

aryl(benzyl)sulfonylacetic acids, aryl(benzyl)sulfonylpropionic acids, phosphorus oxychloride, 1, 3, 4-thiadiazol-2-amines, thiosemicarbazide, cyclization.

Abstract

A series of 1,3,4-thiadiazol-2-amines with substituents containing SO2 group located at position 5 were obtained in good yields (63–81%) by cyclization of aryl(benzyl)sulfonylacetic or aryl(benzyl)sulfonylpropionic acids with thiosemicarbazide in refluxing POCl3.

 

Author Biography

Сергей А. Серков, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991, Russia

Russian Academy of sciences

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Published

2022-10-21

Issue

Vol. 58 No. 10 (2022): Chemistry of polyheteroatomic heterocyclic systems

Section

Original Papers