

SYNTHESIS OF S-SUBSTITUTED 5-SULFONYLMETHYL(ETHYL)-1,3,4-THIADIAZOL-2-AMINES

Abstract
A series of 1,3,4-thiadiazol-2-amines with substituents containing SO2 group located at position 5 were obtained in good yields (63–81%) by cyclization of aryl(benzyl)sulfonylacetic or aryl(benzyl)sulfonylpropionic acids with thiosemicarbazide in refluxing POCl3.
Keywords
aryl(benzyl)sulfonylacetic acids; aryl(benzyl)sulfonylpropionic acids; phosphorus oxychloride; 1,3,4-thiadiazol-2-amines; thiosemicarbazide; cyclization.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv