THE DESIGN AND SYNTHESIS OF 5-(MORPHOLIN-4-YL)-N'-SULFONYL-1,2,3-THIADIAZOLE-4-AMIDINES

Abstract

A strategy was proposed for the synthesis of 5-(morpholin-4-yl)-N'-sulfonyl-1,2,3-thiadiazole-4-imidamides, as well as previously unknown 2thiocarbamoyl acetimidamides. Their reactions with arylsulfonyl azides were studied. In the case of reactions between dimorpholine derivatives of 2-thiocarbamoylacetimidamides and arylsulfonyl azides, diazo transfer did not occur. Instead, a new process was observed, producing the target molecules in one synthetic step via the formation of triazene intermediate and the elimination of ammonia.