

METHYL 3-ARYL(PYRIDYL)-5-OXOPYRROLIDINE-2-CARBOXYLATES: SYNTHESIS AND STRUCTURE

Abstract
A convenient diastereoselective method for the preparation of methyl (2R*,3R*)-3-aryl(pyridyl)-5-oxopyrrolidine-2-carboxylates was developed on the basis of the neutralization reaction of diastereohomogeneous dimethyl (2R*,3R*)-3-aryl(pyridyl)glutamate hydrochlorides.
Keywords
lactams; 5-oxopyrrolidine-2-carboxylates; 2-pyrrolidone; pyroglutamic acid esters.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv