METHOD FOR THE SYNTHESIS OF CHROMENOPYRIMIDINE-FUSED AZOLES BY COPPER-CATALYZED INTRAMOLECULAR HETERO-DIELS–ALDER REACTION

Authors

  • Minoo Khalili Ghomi Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Naeimeh Alizadeh School of Chemistry, College of Science, University of Tehran, P. O. Box 14155-6455, Tehran, Iran
  • Ali Moazzam Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Samanesadat Hosseini Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Saeed Bahadorikhalili Department of Electronic Engineering, Universitat Rovira i Virgili, 43007, Tarragona, Spain
  • Bagher Larijani Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Mahdavi Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

DOI:

https://doi.org/10.1007/6954

Keywords:

aminoazole, chromenopyrimidine, copper catalyst, intramolecular hetero-Diels–Alder reaction.

Abstract

One-pot efficient copper-catalyzed approach for the synthesis of tetracyclic chromeno[4',3':4,5]pyrimido[1,2-b]indazolone and chromeno[4,3-d][1,2,4]triazolo[4,3-a]pyrimidine derivatives as a class of pharmacologically interesting compounds through the intramolecular domino condensation–aza-Diels–Alder reaction of aminoazoles and o-propargylated salicylaldehydes under reflux conditions has been described.

Downloads

Published

2023-05-31

Issue

Vol. 59 No. 4/5 (2023)

Section

Original Papers