SYNTHESIS OF 6,7-DIHYDRO-5H-BENZO[c]-1,2,4-TRIAZOLO[3,4-a]AZEPINES AND 6,7-DIHYDRO-5H-BENZO[c]TETRAZOLO[5,1-a]AZEPINES

Abstract

Cyclization of 1-hydrazinyl-3,3-dimethyl-3,4-tetrahydro-5H-benzo[c]azepine with ethyl orthoformate gave 5,5-dimethyl-6,7-dihydro-5H-benzo[c]-1,2,4-triazolo[3,4-a]azepine, and its reaction with acetic acid afforded 3,5,5-trimethyl-9,10-dimethoxy-6,7-dihydro-5Н-benzo[c]-1,2,4-triazolo[3,4-a]azepine. Nitrosation of 1-hydrazino-3,3-dimethyl-3,4-tetrahydro-5H-benzo[c]azepine led to the formation of substituted 6,7-dihydro-5H-benzo[c]tetrazolo[5,1-a]azepines.

Authors: Vladimir A. Glushkov*, Kseniya A. Mosheva, Mark M. Zaitsev, Vera S. Pelykh, Valeriya I. Karasik, Alexander I. Andreev, Maksim V. Dmitriev