DIVERGENT SYNTHESIS OF 1,5-BENZODIAZEPINES AND BENZIMIDAZOLES via A BICl3-CATALYZED ONE-POT CONDENSATION–CYCLIZATION PROCESS

Abstract

Catalyzed by BiCl3, aromatic o-diamines reacted with ketones efficiently to produce 1,5-benzodiazepines in good to excellent yields by condensation–cyclization reaction. Using aldehydes as substrates, mono- or disubstituted benzimidazoles were obtained as the final products. All reactions were carried out under mild reaction conditions and showed good functional group compatibility.