SELENIUM-CONTAINING AZOLES: SYNTHESIS AND POSSIBILITIES OF APPLICATION

Abstract

The review summarizes and analyzes data published over the last twenty years on the synthesis of functionalized selanyl azoles containing two pharmacophore centers responsible for different pharmacological activities. The design of such molecules with multipurpose action is effected by the improvement and development of new synthesis methods, including those that consider the fundamental principles of green chemistry. The material is systematized according to the methods of synthesis of the claimed selanyl azaheterocycles. The possibilities of practical application of selanyl azoles as a framework for the design of new drugs are discussed.

Authors: Nail S. Akhmadiev, Keshav L. Ameta, Vnira R. Akhmetova*