4-HYDROXY-2-QUINOLONES. 38. SYNTHESIS, STRUCTURE, AND ANTICONVULSANT ACTIVITY OF OPTICALLY ACTIVE 1-PHENYLETHYLAMIDES OF 1-R-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACIDS

Authors

  • И. В. Украинец Ukrainian Pharmaceutical Academy
  • С. Г. Таран Ukrainian Pharmaceutical Academy
  • Н. В. Лиханова Ukrainian Pharmaceutical Academy
  • В. Б. Рыбаков M. V. Lomonosov Moscow State University
  • О. В. Горохова Ukrainian Pharmaceutical Academy
  • Нидаль Амин Джарадат Ukrainian Pharmaceutical Academy

DOI:

https://doi.org/10.1007/72

Keywords:

4-hydroxyquinolone, carbostyril, 1-phenylethylamides, optical activity, X-ray diffraction structural analysis, anticonvulsants

Abstract

A synthesis is reported for optically pure antipodes of 1-phenylethylamides of 1-R-4-hydroxy-2-oxo-3-quinolinecarboxylic acids. An attempt was made to establish the absolute configuration of these products by X-ray diffraction crystallographic analysis. The anticonvulsant activity of the S-enantiomers was studied.

Authors: I. V. Ukrainets, S. G. Taran, N. V. Likhanova, V. B. Rybakov, O. V. Gorokhova, and Nidal Amin Jaradat.

English Translation in Chemistry of Heterocyclic Compounds, 2000, 36 (1), pp 49-56

http://link.springer.com/article/10.1007/BF02256844

 

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Published

2012-09-24

Issue

No. 1 (2000)

Section

Original Papers