THE [3+2] CYCLOADDITION REACTION AS AN ATTRACTIVE WAY FOR THE PREPARATION OF NICOTINE ANALOGS

Abstract

In this microreview, the application of [3+2] cycloaddition reactions in the synthesis of nicotine analogs is critically reviewed and analyzed on the basis of available literature data. It was found that [3+2] cycloaddition with the participation of differently functionalized azomethine ylides is particularly well represented. This enables the synthesis of nicotine analogs not available by other routes.