STEREOSELECTIVE SYNTHESIS OF TETRAHYDROPYRIMIDIN-2(1H)-ONES

Abstract

We provide a generalized overview of stereoselective synthetic strategies used for the preparation of tetrahydropyrimidin-2(1H)-one derivatives, illustrated by the most relevant examples published between years 2012 and 2022. The known methods can be divided into two main groups: intramolecular and intermolecular cyclization of unsaturated acyclic amides/ureas, as well as syntheses on the basis of cyclic precursors.

Authors: Andrey V. Smolobochkin*, Almir S. Gazizov