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5-ARYLMETHYLIDENE-2-IMINOTHIAZOLIDIN-4-ONES IN THE SYNTHESIS OF NOVEL DISPIRO-FUSED OXINDOLEPYRROLIDINEIMINOTHIAZOLIDINONES

Алексей Н. Изместьев, Андрей A. Стрельцов, Ангелина Н. Кравченко, Галина A. Газиева
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Abstract


A novel series of dispiro(indolinonepyrrolidineiminothiazolidinones) were synthesized by 1,3-dipolar cycloaddition of 5-arylmethylidene-2-iminothiazolidin-4-ones and azomethine ylides generated from N-alkylamino acids and isatin derivatives. A number of iminothiazolidinones and dispiro compounds were tested for antiproliferative activity. Seven compounds showed moderate antiproliferative activity at micromolar concentrations against cancer cell lines.

Authors: Alexei N. Izmest'ev, Andrey А. Streltsov, Angelina N. Kravchenko, Galina А. Gazieva*


Keywords


azomethine ylides; iminothiazolidinones; isatins; spirooxindole; antiproliferative activity; 1,3-dipolar cycloaddition

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