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SYNTHESIS OF FUNCTIONALIZED POLYHALOGENATED THIOPHENE DERIVATIVES

Nikita A. Chaika, Kostiantyn V. Shvydenko, Tetiana I. Shvydenko, Aleksandr N. Kostyuk
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Abstract


The halogen dance reaction was utilized for preparation of iodothiophenes. Starting from a set of dihalo-substituted thiophenes, their derivatives, namely, aldehydes, acids, and 2,5-diiodothiophenes, were obtained. Formyl derivatives of thiophenes served as the basis for the synthesis of a number of previously unknown (difluoromethyl)- and (chloromethyl)thiophenes. Convenient and simple synthetic procedures were developed for a set of functionalized thiophenes.


Keywords


diethylaminosulfur trifluoride; diiodothiophenes; polyhalogenated thiophenes; formylation; halogen dance reaction.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv