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METHOD OF THE SYNTHESIS OF SELENIUM HOMOLOG OF RUCAPARIB

Sindija Lapcinska, Pavel Arsenyan
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Abstract


We have developed a practical protocol from readily available 5-fluoro-2-hydroxybenzoic acid to access a selenium homolog of rucaparib. The crucial step is Lewis acid mediated 5-endo-dig cyclization of ethynyl aniline with the following intramolecular electrophilic selenylation leading to the one-pot construction of a tricyclic system.

Keywords


rucaparib; selenium; electrophile; 5-endo-dig; one-pot synthesis.

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