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И. Стракова, М. Петрова, С. Беляков, А. Страков


A  new method is reported for the synthesis of 2-R-substituted [1]benzopyrano[4,3-d]pyrimidin-5-ones (R = p-phenyl, p-chlorophenyl-,  p-carbamoylphenyl-, 3-pyridinyl-, 4-pyridinyl-, 2-pyrazinyl-,  pyrrolidino-, morpholino-,  3,6-dimethyl-1-pyrazolyl-) by the reaction of 4-chloro-3-formylcoumarin with salts of the corresponding amidines RC(=NH)NH2HX  in  DMF  in  the presence of piperidine or triethylamine. 3-Formyl-4-coumarin and 2-aminobenzimidazole give  [1]benzopyrano[2,4:3',4']-pyrimido[1,2-a]-benzimidazol-6-one, whose structure was demonstrated by X-ray diffraction structural analysis.

How to Cite
Strakova, I.; Petrova, M.; Belyakov, S.; Strakovs, A.  Chem. Heterocycl. Compd. 2007, 43, 793. [Khim. Geterotsikl. Soedin. 2007, 935.]

For this article in the English edition see DOI 10.1007/s10593-007-0128-4


2-substituted [1]benzopyrano[4,3-d]pyrimidin-5-ones; benzene and heterocyclic C- and N-carbamidines; 4-chloro-3-formylcoumarins

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