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Н. В. Горбуленко, Т. М. Ткачук, Т. В. Шокол, В. В. Семенюченко, А. В. Туров, В. П. Хиля


The interaction has been studied of a series of substituted 3-hetaryl-7-hydroxychromones with amino acids and formaldehyde (reactants ratio 1 : 1 : 2 respectively). In the case of glycine and Het = 3-isoxazolyl the product of aminomethylation at position 8 of the chromone was obtained, and with other Het (including Het = 4-phenyl-1,2,4-triazol-3-yl)  2-[6-alkyl-3-hetaryl-4-oxo-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]-
oxazin-9-yl]acetic acids were formed. With  β-alanine and Het = 4-phenyl-1,2,4-triazol-3-yl the corresponding  β-substituted propionic acid was synthesized, but proline did not participate in the reaction, leading to bis(6-ethyl-3-hetaryl-7-hydroxychromon-8-yl)methane.

How to Cite
Gorbulenko, N. V.; Tkachuk, T. M.; Shokol, T. V.; Semeniuchenko, V. V.; Turov, A. V.; Khilya, V. P.  Chem. Heterocycl. Compd. 2007, 43, 569. [Khim. Geterotsikl. Soedin. 2007, 683.]

For this article in the English edition see DOI 10.1007/s10593-007-0091-0


amino acids; 3-hetaryl-7-hydroxychromones; 3-hetaryl-4-oxo-9,10-dihydro-4H,8H-chromeno[8,7-e][1,3]oxazines; Mannich reaction; formaldehyde

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