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SYNTHESIS OF OCTAHYDROPYRROLO[3,4-c]PYRROLES BY THERMOLYSIS OF N-PHTHALIMIDOAZIRIDINES BASED ON 5-ALKENYL-1,2,4-OXADIAZOLES

Вера В. Сиднева, Марина В. Тарасенко, Алена С. Панькова, Евгений Р. Кофанов
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Abstract


N-Phthalimidoaziridines were synthesized from 3,5-disubstituted 1,2,4-oxadiazoles containing alkenyl and pyridine fragments. N-Phthalimidoaziridines were heated in the presence of N-arylmaleimide to give the corresponding N-phthalimidopyrrolidines. The synthesized N-phthalimidoaziridines and N-phthalimidopyrrolidines contain several pharmacophoric groups (the aziridine, oxadiazole, pyridine, and phthalimide moieties) making them potential active ingredients of medicines.

 


Keywords


5-alkenyl-1,2,4-oxadiazoles; 3,5-disubstituted 1,2,4-oxadiazoles; N-phthalimidoaziridines; N-phthalimidopyrrolidines; octahydropyrrolo[3,4-c]pyrroles; oxidative aminoaziridination.

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