SOLVENT-FREE SYNTHESIS OF NOVEL 5-OXO-5<i>H</i>-CHROMENO[4,3-<i>b</i>]PYRIDINE DERIVATIVES

Abstract

An efficient and simple method for the synthesis of new 5-oxo-5H-chromeno[4,3-b]pyridine derivatives via Michael addition of 4-aminocoumarin to arylidenemalononitrile for 20 min at 150°C without any solvent is proposed. The advantages of this procedure are mild reaction conditions, high yields of products, and operational simplicity.

Also published in Chemistry of Heterocyclic Compounds, 2013, 48 (12), pp 1839-1843

http://link.springer.com/article/10.1007/s10593-013-1217-1