4-HYDROXY-2-QUINOLONES. 220. BROMINATION OF ETHYL 7-HYDROXY-5-OXO-2,3-DIHYDRO-1<i>H</i>,5<i>H</i>-PYRIDO[3,2,1-<i>ij</i>]QUINOLINE-6-CARBOXYLATE

Authors

  • И. В. Украинец National University of Pharmacy
  • Н. Ю. Голик National University of Pharmacy
  • И. Н. Черненок National University of Pharmacy
  • С. В. Шишкина Scientific-Technological Complex "Institute of Monocrystals", National Academy of Sciences of Ukraine
  • В. А. Паршиков S. I. Georgievsky Crimean State Medical University

DOI:

https://doi.org/10.1007/882

Keywords:

4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids, pyrido[3, 2, 1-ij]quinolines, bromination

Abstract

Treatment of ethyl 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylate with bromine in aqueous acetic acid solution gave not only the expected ethyl 2‑bromo-1,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate, but also an admixture of its 9-bromo-substituted isomer. The structural features of the major and minor reaction products are discussed.

Authors: I. V. Ukrainets, N. Yu. Golik, I. N. Chernenok, S. V. Shishkina, and V. A. Parshikov

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (11), pp 1665-1669

http://link.springer.com/article/10.1007/s10593-013-1190-8

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Published

2013-08-23

Issue

No. 11 (2012)

Section

Original Papers