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THE SYNTHESIS AND CYTOTOXIC PROPERTIES OF SELENOPHENO[3,2-c]- AND SELENOPHENO[2,3-c]QUINOLONES

П. Арсенян, Е. Васильева, И. Шестакова, И. Домрачева, С. Беляков
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Abstract


We have developed a method for the synthesis of novel selenophene-containing polycyclic heterocycles, derivatives of selenopheno[3,2-c]- and selenopheno[2,3-c]quinolones. The cytotoxic activity of these compounds was studied in vitro. The molecular structure of 3-bromo-5-methyl-2-(piperidin-2‑ylmethyl)selenopheno[3,2-c]quinolin-4(5H)-one was confirmed by X-ray analysis.

How to Cite
Arsenyan, P.; Vasiljeva, J.; Shestakova, I.; Domracheva, I.; Belyakov, S. Chem. Heterocycl. Compd. 2014, 49, 1674. [Khim. Geterotsikl. Soedin. 2013, 1804.]

For this article in the English edition see DOI 10.1007/s10593-014-1419-1


Keywords


quinolone; selenium; selenophene; cytotoxicity; electrophilic addition; intramolecular cyclization; X-ray structural analysis

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