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ALKYLATION OF TETRAHYDROPYRIMIDINE-2-THIONES WITH ETHYL CHLOROACETATE

А. К. Ширяев, Н. Г. Колесникова, Н. М. Кузнецова, Е. А. Лашманова
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Abstract


Reaction conditions were found for the alkylation of tetrahydropyrimidine-2-thiones with ethyl chloroacetate, preventing a subsequent cyclization. Only one of the ester groups in the obtained alkylation products was subject to alkaline hydrolysis, while a treatment with ammonia in alcohol resulted in thiazolo[3,2‑a]pyrimidines.

How to Cite
Shiryaev, A. K.; Kolesnikova, N. G.; Kuznetsova, N. M.; Lashmanova, E. A. Chem. Heterocycl. Compd. 2014, 49, 1681. [Khim. Geterotsikl. Soedin. 2013, 1812.]

For this article in the English edition see DOI 10.1007/s10593-014-1420-8


Keywords


dihydropyrimidines; esters of haloacetic acids; tetrahydropyrimidine-2-thiones; thiazolo[3,2-a]pyrimidines; alkylation; hydrolysis

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