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SYNTHESIS OF SOME NEW HETEROCYCLIC COMPOUNDS DERIVED FROM 3-FORMYLCHROMONES AND THEIR ANTIMICROBIAL EVALUATION

A. Bari, S. S. Ali, A. Kadi, I. Ali Hashmi, S. W. Ng
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Abstract


The synthesis and antimicrobial evaluation of a series of various chromone-linked substituted heterocyclic derivatives is described. The condensation of 3-formylchromone with acetoacetamide under Knoevenagel–Cope reaction conditions was also explored, and the condensation with 4-hydroxy-6-methyl-2H-pyran-2-one constitutes a facile route to pyranopyrone fused system. Most of the compounds exhibit good antimicrobial properties.

How to Cite
Bari, A.; Ali, S. S.; Kadi, A.; Hashmi, I. A.; Ng, S. W. Chem. Heterocycl. Compd. 2014, 49, 1723. [Khim. Geterotsikl. Soedin. 2013, 1860.]

For this article in the English edition see DOI 10.1007/s10593-014-1424-4

 


Keywords


3-formylchromone; pyranopyrones; antimicrobial activity; enzyme inhibitors; Knoevenagel–Cope reaction; pharmacophore; urease inhibitory

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