Open Access Open Access  Restricted Access Subscription Access

GUANIDINE HYDROCHLORIDE CATALYZED, RAPID AND EFFICIENT ONE-POT SYNTHESIS OF NAPHTHOXAZINONES UNDER SOLVENT-FREE CONDITIONS

A. Olyaei, M. Sadeghpour, M. Zarnegar
Cover Image

Abstract


A novel method for the synthesis of 1-aryl-1,2-dihydro-3H-naphtho[1,2-e][1,3]oxazine-3‑one derivatives employing one-pot three-component reaction of β-naphthol, aromatic aldehydes, and urea using a catalytic amount of guanidine hydrochloride under solvent-free thermal conditions is described. This method provides several advantages like clean and environmentally benign reaction, simple work-up procedure, low cost, easy product separation without need of further purification with column chromatography, shorter reaction times, and high yields.

Keywords


aldehyde; guanidine hydrochloride; naphthol; naphthoxazinone; solvent-free reaction

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv