Synthesis and properties of 2-substituted 1-aryl-7,8-dihydro-6H-pyrimido[4,5-b]pyrindine-4-ones

Authors

  • P. Н. Гaлеева Perm Pharmaceutical Academy, Perm 614000
  • М. Ю. Гаврилов Perm Pharmaceutical Academy, Perm 614000
  • E. B. Фешина Institute of Technical Chemistry, Perm 614000
  • М. Е. Коньшин Perm Pharmaceutical Academy, Perm 614000

Abstract

In reaction with acylating agents, 2-aryl-2-methyl-7,8-dihydro-6H-pyrimido[4,5-b]pyrindin-4-ones are acylated at the methyl group and also enter into reaction with diethyl oxalate. 1-Aryl-2-phenacyl-7,8-dihydro-6H-pyrimido[4,5-b]pyrindin-4-ones undergo dehydration under the influence of concentrated sulfuric acid. On the basis of the PMR and UV spectra, it was concluded that 1-aryl-2-acetonyl(phenacyl)-7,8-dihydro-6H-pyrimido[4,5-b]pyrindin-4-ones exist in two tautomeric forms with strong intramolecular hydrogen bonds of the chelate type — enaminocarbonyl and enol.

How to Cite
Galeeva, R. N.; Gavrilov, M. Y.; Feshina, E. V.; Kon'shin, M. E. Chem. Heterocycl. Compd. 1997, 33, 1199. [Khim. Geterotsikl. Soedin. 1997, 1380.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02290870

Downloads

Published

1997-10-25

Issue

No. 10 (1997)

Section

Original Papers