Synthesis of 4,6-bis(1H-1,2,3-triazolyl)pyrimidines by the reaction of 4,6-diazido-2-(4-methoxyphenyl)-pyrimidine with compounds containing a reactive methylene group

Authors

  • E. Б. Николаенкова Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090
  • B. П. Кривопалов Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090

Abstract

The reaction of 4,6-diazido-2-(4-methoxyphenyl)pyrimidine with cyanoacetic ester in the presence of triethylamine leads only to 4-azido-6-amino-1-(4-methoxyphenyl)pyrimidine. The main product in reactions with 1,3-dicarbonyl compounds (acetylacetone, acetoacetic and benzoylacetic esters) is the corresponding substituted 4,6-bis(1H-1,2,3-triazolyl)pyrimidine. The formation of 4-azido-6-(1H-1,2,3-triazolyl)pyrimidine and 4-amino-6-(1H-1,2,3-triazolyl)pyrimidine as minor products was also recorded.

How to Cite
Nikolaenkova, E. B.; Krivopalov, V. P. Chem. Heterocycl. Compd. 1997, 33, 968. [Khim. Geterotsikl. Soedin. 1997, 1109.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02253171

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Published

1997-08-25

Issue

No. 8 (1997)

Section

Original Papers