ANTIBACTERIAL EFFICIENCY OF COMPOUNDS BEARING 1,2,3-TRIAZOLE SCAFFOLD: A CRITICAL REVIEW

Abstract

In line with the development of metal-catalyzed Huisgen's (3+2) cycloaddition reaction, the 1,2,3-triazoles have emerged as an important class of nitrogen-containing heterocycles with significant potential as antibacterial agents. Copper(I)-catalyzed azide–alkyne cycloaddition, a flagship example of click chemistry, has enabled the rapid and regioselective synthesis of diverse molecular scaffolds containing the 1,2,3-triazole moiety. This review highlights recent advances in the synthesis of 1,4-disubstituted 1,2,3-triazoles exhibiting antibacterial properties via click chemistry. Special attention is given to reaction conditions that lead to optimal results. The versatility and modularity of click chemistry have resulted in the growing popularity of this approach in the design of novel structureswith antibacterial activity.