Synthesis and conversions of 2-substituted cinchoninic acid amides

Abstract

Amides of 2-oxo- or 2-thiocinchoninic acid have been obtained by the reaction of substituted amides of 2-chlorocinchoninic acid with sodium acetate or sodium sulfide. The reaction of 2-thiocinchoninic acid amides with hydrazine hydrate or ethyl cyanoacetate leads to derivatives of 2-hydrazinocinchoninic acid or (4-carbamoyl-2-quinolyl)cyanoacetic ester respectively, which were also obtained from 2-chlorocinchoninic acid amides.

How to Cite
Mikhalev, A. I.; Kon'shin, M. E.; Vakhrin, M. I. Chem. Heterocycl. Compd. 1997, 33, 605. [Khim. Geterotsikl. Soedin. 1997, 697.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02291947