Synthesis of steroids containing a vicinal diol group in the side chain via isoxazoline intermediates

Authors

  • P. П. Литвиновская Institute of Bioorganic Chemistry, Academy of Sciences of Belarus, 220141 Minsk
  • C. B. Драч Institute of Bioorganic Chemistry, Academy of Sciences of Belarus, 220141 Minsk
  • H. В. Кoваль Institute of Bioorganic Chemistry, Academy of Sciences of Belarus, 220141 Minsk
  • В. А. Хрипач Institute of Bioorganic Chemistry, Academy of Sciences of Belarus, 220141 Minsk

Abstract

A sequence of conversions including 1,3-dipolar cycloaddition of nitrile oxides to steroid 22-enes and modification of the isoxazolines obtained by hydroxylation to the 4′ position and splitting of the heterocycle leads to steroids with a polyfunctional open chain, 22,23-dihydroxy 24-ketones.

How to Cite
Litvinovskaya, R. P.; Drach, S. V.; Koval', N. V.; Khripach, V. A. Chem. Heterocycl. Compd. 1997, 33, 465. [Khim. Geterotsikl. Soedin. 1997, 542.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02321394

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Published

2025-10-22

Issue

No. 4 (1997)

Section

Original Papers