Synthesis of unsaturated adenine derivatives, potential inhibitors of S-adenosyl-L-homocysteine hydrolase

Abstract

The synthesis of 9-substituted adenine derivatives, containing an unsaturated fragment at the end of the acyclic chain, is described; it consists of the alkylation of adenine salts with unsaturated α-haloethers, tosylates, and epoxides. It was shown that compounds of this series possess moderate antiviral activity.

How to Cite
Ozerov, A. A.; Novikov, M. S. Chem. Heterocycl. Compd. 1996, 32, 712. [Khim. Geterotsikl. Soedin. 1996, 826.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01164872