Reaction of 1-methylthio-3,4-dihydroisoquinolines with amines

Authors

  • Ю. B. Шкляев Institute of Technical Chemistry, Urals Branch, Russian Academy of Sciences, Perm' 614000
  • B. А. Глушков Institute of Technical Chemistry, Urals Branch, Russian Academy of Sciences, Perm' 614000
  • Н. Б. Белогуб Institute of Technical Chemistry, Urals Branch, Russian Academy of Sciences, Perm' 614000
  • И. Л. Мисюра Institute of Technical Chemistry, Urals Branch, Russian Academy of Sciences, Perm' 614000

Abstract

A study was carried out on the reaction of 1-methylthio-3,4-dihydroisoquinolines with aromatic and aliphatic amines, thiourea, semicarbazide, and thiosemicarbazide. The reactions with anthranilic acid and 2-amino-3-carboethoxy-4,5-dmeurylthiophene give 6,6-dmethyl-5,6-dihydro-8H-isoquino[1,2-b]quinazolin-8-one and 6, 6, 9,10-tetramethyl-5,6-dihydro-8H-benzo[i]thieno[2,3-b]quinolizin-8-one, respectively. 1-Semicarbazido-and 1-thiosemicarbazido-3,4-dihydroisoquinolines were shown to undergo thermal elimination of ammonia to give substituted 1,2,4-triazolo[3, 4-a]isoquinolin-3-ones and 1, 2, 4-triazolo[3,4-a]isoquinoline-3-thiones.

How to Cite
Shklyaev, Y. V.; Glushkov, V. A.; Belogub, N. B.; Misyura, I. L. Chem. Heterocycl. Compd. 1996, 32, 689. [Khim. Geterotsikl. Soedin. 1996, 800.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01164868

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Published

1996-06-25

Issue

No. 6 (1996)

Section

Original Papers