Investigation of bisheteryl derivatives of piperazine and its analogs. 2. Synthesis and properties of bis(dialkyldithiocarbamoyl-5-nitro-4-pyrimidyl)piperazines

Authors

  • B. А. Макаров Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • А. Л. Седов Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • М. П. Немерюк Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • H. П. Соловьева Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • O. C. Анисимова Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • Т. С. Сафонова Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815

Abstract

The corresponding 6-dialkyldithiocarbamoyl derivatives are obtained by reacting N,N′bis(2-R-6-chloro-5-nitro-4-pyrimidyl)carbamates. in one example it was shown that these products may be rearranged on heating with the formation of the bis(1,3-dithiolo[4,5-d]pyrimidyl)piperazine system, and in the presence of an alkaline catalyst may be converted by fission of the pyrimidine ring into the highly polarized N,N′-bis(1-amino-2-cyano-2-nitro-1-ethenyl)piperidine.

How to Cite
Makarov, V. A.; Sedov, A. L.; Nemeryuk, M. P.; Solov'eva, N. P.; Anisimova, O. S.; Safonova, T. S. Chem. Heterocycl. Compd. 1995, 31, 180. [Khim. Geterotsikl. Soedin. 1995, 208.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169676

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Published

1995-02-25

Issue

No. 2 (1995)

Section

Original Papers