4-Hydroxy-2-quinolones. 20. Synthesis and chemical conversions of ehtyl esters of the chloro-substituted quinoline-3-carboxylic acids

Authors

  • И. B. Украинец Ukrainian Pharmaceutical Academy, Kharkov 310002
  • C. Г. Таран Ukrainian Pharmaceutical Academy, Kharkov 310002
  • O. B. Горохова Ukrainian Pharmaceutical Academy, Kharkov 310002
  • Н. А. Марусенко Ukrainian Pharmaceutical Academy, Kharkov 310002
  • C. Н. Коваленко Ukrainian Pharmaceutical Academy, Kharkov 310002
  • А. B. Туров Ukrainian Pharmaceutical Academy, Kharkov 310002
  • H. И. Филимонова Ukrainian Pharmaceutical Academy, Kharkov 310002
  • C. М. Ивков Ukrainian Pharmaceutical Academy, Kharkov 310002

Abstract

Preparative methods for the synthesis of ethyl esters of 2,4-dichloro- and 2-oxo-4-chloroquinoline-3-carboxylic acids were developed. The behavior of the compounds indicated was studied under conditions of alkaline and acidic hydrolysis, in reactions with some nucleophilic reagents, as well as in reductive dehalogenation. Results of the study of the antimicrobial and anti-inflammatory activity of the synthesized compounds are presented.

How to Cite
Ukrainets, I. V.; Taran, S. G.; Gorokhova, O. V.; Marusenko, N. A.; Kovalenko, S. N.; Turov, A. V.; Filimonova, N. I.; Ivkov, S. M. Chem. Heterocycl. Compd. 1995, 31, 167. [Khim. Geterotsikl. Soedin. 1995, 195.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169674

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Published

1995-02-25

Issue

No. 2 (1995)

Section

Original Papers