Investigation of bis-heteryl derivatives of piperazine and its analogs. 1. Synthesis and conversions of N,N<sup>1</sup>-bis(2-R-5-nitro-6-pyrimidinyl)piperazines and N,N<sup>3</sup>-bis(2-R-5-nitro-6-pyrimidinyl)dispirotripiperazinium dichloride

Authors

  • B. А. Макаров Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • А. Л. Седов Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • M. П. Немерюк Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • T. C. Сaфонова Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815

Abstract

A method has been developed for the synthesis of some N,N′-bis(5-nitro-6-pyrimidinyl) derivatives of piperazine and dispirotripiperazinium dichloride containing a chlorine atom in the 4 position of the pyrimidine ring. It has been shown possible to react them with various nucleophilic reagents with the formation of the corresponding dialkylamino derivatives.

How to Cite
Makarov, V. A.; Sedov, A. L.; Nemeryuk, M. P.; Safonova, T. S. Chem. Heterocycl. Compd. 1994, 30, 841. [Khim. Geterotsikl. Soedin. 1994, 971.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169643

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Published

1994-07-25

Issue

No. 7 (1994)

Section

Original Papers