Synthesis of a new heterocyclic system of 2-amino-3-cyano-5H-4,5-dihydropyrido[3′,2′:4,5]pyrrolo[1,2-<i>a</i>]indole

Authors

  • Н. З. Тугушева Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • C. Ю. Рябова Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • Н. П. Соловьева Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815
  • В. Г. Граник Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815

Abstract

Alkylation of 2-piperidinomethylene-2H-pyrrolo[1,2-a]indole-3,9-dione with dimethyl sulfate, followed by hydrolysis of the intermediate immonium salts, yielded 2-formyl derivatives, the reaction of which with substances possessing on active methylene unit leads to the formation of 2-substituted vinyl-3-oxo-9-alkoxypyrrolo[1,2-a]indoles. Cyclization of the 9-methoxy derivative yielded a new heterocyclic system of 2-amino-3-cyano-5H-4,5-dihydropyrodol[3′2′:4,5]pyrroloindoledione-4,11.

How to Cite
Tugusheva, N. Z.; Ryabova, S. Yu.; Solov'eva, N. P.; Granik, V. G. Chem. Heterocycl. Compd. 1994, 30, 793. [Khim. Geterotsikl. Soedin. 1994, 919.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169636

Downloads

Published

1994-07-25

Issue

No. 7 (1994)

Section

Original Papers