Wolff-Kishner reduction of 5-methyl- and 6,6-dimethyl-5-hydroxy-4-oxo-3-phenylpyrrolidino[1,2-<i>b</i>]pyrazoles

Abstract

The reduction of 5-hydroxy-5-methyl-4-oxo-3-phenylpyrrolidino[1,2-b]pyrazole by heating with hydrazine hydrate in alkaline solution is accompanied by fission of the bicyclic skeleton or by dehydration depending on the solvent and reaction temperature. A two-stage synthesis of 6,6-dimethyl-3-phenyl-pyrrolidino[1,2-b]pyrazole from 5-hydroxy-6,6-dimethyl-4-oxo-3-phenylpyrrolidino[1,2-b]pyrazole is proposed.

How to Cite
Kuz'menok, N. M.; Zvonok, A. M. Chem. Heterocycl. Compd. 1993, 29, 1152. [Khim. Geterotsikl. Soedin. 1993, 1345.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF00538059