SYNTHESIS OF PYRROLO[2,3-<i>d</i>]PYRIMIDINES WITH 3-AMINO-2-HYDROXYPROPYL SUBSTITUENTS

Authors

  • Л. В. Музычка Institute of Bioorganic and Petroleum Chemistry, Ukraine National Academy of Sciences
  • Е. В. Вервес Institute of Bioorganic and Petroleum Chemistry, Ukraine National Academy of Sciences
  • И. О. Яремчук Institute of Bioorganic and Petroleum Chemistry, Ukraine National Academy of Sciences
  • О. Б. Смолий Institute of Bioorganic and Petroleum Chemistry, Ukraine National Academy of Sciences

DOI:

https://doi.org/10.1007/1242

Keywords:

pyrimido[5', 4', 4, 5]pyrrolo[2, 1-c][1, 4]oxazines, pyrrolo[2, 3-d]pyrimidines, bromolactonization

Abstract

A novel route has been found for the synthesis of pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazines. They are promising reagents for the preparation of pyrrolo[2,3-d]pyrimidine-6-carboxylic acid amides which contain a 3-amino-2-hydroxypropyl substituent in position 7 of the heterocyclic ring.

Authors: L. V. Muzychka, E. V. Verves, I. O. Yaremchuk, and O. B. Smolii.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (3), pp 481-487

http://link.springer.com/article/10.1007/s10593-012-1019-x

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Published

2013-11-26

Issue

No. 3 (2012)

Section

Original Papers