SYNTHESIS OF 3-ALKOXYCARBONYL-6-ALKYLSULFANYL-4-(2-DIFLUOROMETHOXYPHENYL)-1,4-DIHYDROPYRIDINES AND RELATED DERIVATIVES AS ANALOGUES OF COGNITION ENHANCER CEREBROCRAST

Authors

  • A. Krauze Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006
  • Z. Andžāns Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006
  • L. Krasnova Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006
  • S. Ģērmane Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006
  • I. Domračeva Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006
  • I. Adlere Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006
  • S. Grīnberga Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006
  • G. Duburs Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

DOI:

https://doi.org/10.1007/127

Abstract

4-(2-Difluoromethoxyphenyl) substituted 3-alkoxycarbonyl-6-alkylsulfanyl-3-cyano-2-methyl-1,4-dihydropyridines 2, related pyridines 2 and 4,7-dihydrothieno[2,3-b]pyridines 3 have been prepared and their memory improving activity by making use passive avoidance responses in acquisition test and calcium overload preventing activity in SH-SY5Y neuroblastoma cell line in presence of agonist carbachol were examined. 1,4-Dihydropyridines 2f,i bearing propoxyethoxycarbonyl group in position 3 and possessing weak influence on calcium overload in neuronal cells, showed high activity comparable with that of cerebrocrast.

Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (4), pp 566-573

http://link.springer.com/article/10.1007/s10593-013-1283-4

Author Biographies

A. Krauze, Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

Aivars Krauze

Z. Andžāns, Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

Zigmārs Andžāns

L. Krasnova, Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

Laura Krasnova

S. Ģērmane, Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

Skaidrīte Ģērmane

I. Domračeva, Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

Ilona Domračeva

I. Adlere, Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

Ilze Adlere

S. Grīnberga, Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

Signe Grīnberga

G. Duburs, Latvian Institute of Organic Synthesis Aizkraukles 21, Riga LV-1006

Gunārs Duburs

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Published

2013-04-16

Issue

No. 4 (2013)

Section

Original Papers