HETEROCYCLES IN DRUGS AND DRUG DISCOVERY

Abstract

Heterocycles are common fragments of the vast majority of marketed drugs. This is a reflection of a central role that heterocycles play in the modern drug design. They can serve as useful tools to manipulate lipophilicity, polarity and hydrogen bonding capacity of molecules, which may lead to improved pharmacological, pharmacokinetic, toxicological, and physicochemical properties of drug candidates and ultimately drugs.

Also published in Chemistry of Heterocyclic Compounds, 2012, 48 (1), pp 7-10

http://link.springer.com/article/10.1007/s10593-012-0960-z