NEW METHODOLOGY OF FUNCTIONALIZATION OF THE IMIDAZOLE RING BY ALKYNES

Authors

  • B. A. Trofimov A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of Russian Academy of Sciences
  • L. V. Andriyankova A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of Russian Academy of Sciences
  • K. V. Belyaeva A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of Russian Academy of Sciences

DOI:

https://doi.org/10.1007/1309

Keywords:

carbenes, electron-deficient acetylenes, imidazoles, zwitterions, functionalization, multicomponent reactions, nucleophilic addition, (C-2)-vinylation

Abstract

A new methodology for functionalization of the imidazole ring via the zwitterionic intermediates and their carbene tautomers generated by nucleophilic addition of 1-substituted imidazoles to electron-deficient acetylenes followed by the reactions with appropriate electrophiles is discussed.

Also published in Chemistry of Heterocyclic Compounds, 2012, 48 (1), pp 147-154

http://link.springer.com/article/10.1007/s10593-012-0978-2

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Published

2013-12-05

Issue

No. 1 (2012)

Section

Review Articles