SYNTHESIS AND ANTI-HEPATITIS B VIRUS ACTIVITY OF NEW PYRIMIDINE PEPTIDE NUCLEIC ACID ANALOGS
Keywords:peptide nucleic acid analogs, pyrimidine nucleobases, anti-hepatitis B virus activity
A series of 4-methylsulfanylpyrimidin-2(1H)-one peptide nucleic acid analogs were synthesized and tested for their antiviral activity against hepatitis B virus. Plaque reduction infectivity assay was used to determine the virus count reduction as a result of treatment with tested compounds.
Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (10), pp 1290-1297