MODIFIED METHOD FOR THE SYNTHESIS OF ISOMERIC <i>N</i>-SUBSTITUTED (1<i>H</i>-PYRAZOLYL)PROPANE-1,3-DIONES

Abstract

The condensation reaction of isomeric N-substituted (1H-pyrazol-4-yl)ethanones with the ethyl esters of pyrazole carboxylic acids and fluoroacetic acids has been studied using NaH as the base. Under optimized conditions, it proved to be a convenient and preparative method for the synthesis of N-substituted (1H-pyrazolyl)propane-1,3-diones and (1H-pyrazolyl)-4-polyfluorobutane-1,3-diones.

Authors: I. V. Taydakov and S. S. Krasnoselsky

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (6), pp 695-699

http://link.springer.com/article/10.1007/s10593-011-0821-1