AN EFFICIENT SYNTHESIS OF 2,4'-BI-1,3-OXA(THIA)ZOLES AS SCAFFOLDS FOR BIOACTIVE PRODUCTS

Abstract

A rapid and efficient methodology to prepare 2,4'-bi-1,3-azoles as scaffolds for biologically active marine natural products is described. Hantzsch reaction and oxidative cyclodehydration of β-hydroxy amides or thioamides were used to construct the azole rings. The obtained biheterocycles displayed no cytotoxicity on HCT-15 cell line.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (6), pp 703-709

http://link.springer.com/article/10.1007/s10593-011-0823-z