SYNTHESIS OF 2-QUINOLINECARBOXAMIDE DERIVATIVES AS POTENTIAL HDAC INHIBITORS
Keywords:inhibitors of histone deacetylase, quinoline, Zn2 chelating groups
Inhibition of histone deacetylase activity appears as an original and effective approach for the treatment of cancer. A series of novel quinoline-containing derivatives has been synthesized and found that some of these compounds possess nanomolar histone deacetylase inhibitory activity.
Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (6), pp 719-727