ONE-POT CHEMOSELECTIVE SYNTHESIS OF NOVEL FUSED PYRIMIDINE DERIVATIVES

Abstract

One-pot triple-component reaction of 4-hydroxycoumarin with aromatic aldehydes and 2-aminobenzimidazole, 3-amino-1H-1,2,4-triazole, or 6-aminouracil in acetonitrile in the presence of catalytic amounts of sulfamic acid led to a chemoselective synthesis of chromeno[4,3-d]pyrimidine-6-one, triazolo[1,5-a]pyrimidin-5-one, and pyrido[2,3-d]pyrimidine-2,4,7-trione derivatives, respectively, in good yields.

Also published in Chemistry of Heterocyclic Compounds, 2011, 47 (6), pp 737-744

http://link.springer.com/article/10.1007/s10593-011-0828-7