SYNTHESIS OF PYRIMIDO[2,1-<i>b</i>][1,3,5]THIADIAZINES CONTAINING POLYFLUOROALKYL- AND AMINO ACID FRAGMENTS

Authors

  • О. Г. Худина I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
  • А. Е. Иванова I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
  • Я. В. Бургарт I.Ya. Postovskii Organic Synthesis Institute of Ural Branch of Russian Academy of Sciences
  • В. И. Салоутин I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences

DOI:

https://doi.org/10.1007/1695

Keywords:

amino acids, formaldehyde, pyrimido[2, 1-b]thiadiazines, 6-polyfluoroalkyl-2-thiouracils, Mannich reaction, tuberculostatic activity

Abstract

8-Polyfluoroalkylpyrimido[2,1-b][1,3,5]thiadiazine-6-ones containing a structural fragment of amino acid or its ester were synthesized by a multicomponent cyclization of 6-polyfluoroalkyl-2-thiouracils with formaldehyde and amines. The use of diamino acids allowed the preparation of bis(pyrimido-[2,1‑b][1,3,5]thiadiazin-6‑ones), containing an aliphatic linker with a carboxy group. Two of the synthesized compounds exhibited weak antituberculosis activity in vitro.

How to Cite
Khudina, O. G.; Ivanova, A. E.; Burgart, Ya. V.; Saloutin, V. I. Chem. Heterocycl. Compd. 2014, 50, 901. [Khim. Geterotsikl. Soedin. 2014, 976.]

For this article in the English edition see DOI 10.1007/s10593-014-1544-x

Author Biographies

О. Г. Худина, I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences

Ольга Георгиевна Худина

старший научный сотрудник, кандидат химических наук

А. Е. Иванова, I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences

Анна Евгеньевна Иванова

аспирант

Я. В. Бургарт, I.Ya. Postovskii Organic Synthesis Institute of Ural Branch of Russian Academy of Sciences

Янина Валерьевна Бургарт

ведущий научный сотрудник, доктор химических наук

В. И. Салоутин, I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences

Виктор Иванович Салоутин

профессор, доктор химических наук, зам. директора

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Published

2014-06-20

Issue

No. 6 (2014)

Section

Original Papers